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Using the Horadric Cube is simple and only requires you to add the items you intend for transmutation.
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Diablo 2 Resurrected Horadric Cube - How to Use the Horadric Cube You can get another one from the Halls of the Dead again in Act 2 or obtain one in the fifth quest of Act 3. You can only carry one Horadric Cube at a time, but if you happen to lose or get rid of the initial one, Diablo 2 gives you two additional chances to recover the Cube. Bloodwitch the Wild guards the Cube, though you can technically get around her and her spawn to grab the Cube - if you're lucky.
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The first Horadric Cube is impossible to miss, since you need it for the Act 2 story quest that requires the Horadric Staff.
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Video player Diablo 2 Resurrected Horadric Cube - Horadric Cube Locations
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